0324 sleep duration and brain MRI biomarkers: results from SOL-INCA MRI study

Abstract Introduction Long and short sleep have been associated with stroke dementia. Sleep patterns may differ by sex Hispanic/Latino background. Within Hispanics/Latinos heterogeneity in outcomes exists is understudied. The purpose of this study was to examine associations between duration MRI biomarkers brain health. Methods SOL-Investigation Neurocognitive Aging (SOL-INCA) an ongoing ancillary the Hispanic Community Health Study/Study Latinos (HCHS/SOL). Our analytic sample consisted 1,103 adults 50-years older from diverse Hispanics/Latino backgrounds that completed baseline assessments (2008-2011) underwent neuroimaging (2018-ongoing; Mean age 64 ±6.9 years). main exposures were self-reported average nightly duration. Outcomes included volume measures residualized for cranial (e.g. total brain, hippocampal, white matter hyperintensities). Brain modeled, using regression techniques, as a function adjusting age, sex, education, background, language use, cardiovascular events, BMI, depressive symptoms, Apena/Hypopena index quality. Results 7.7 ± 1.36 hours, 13.2% reported sleeping >9 hours. Increasing smaller (Btotal_brain -1.32 [-2.33 ; -0.32], p<0.05) per hour increment larger lateral ventricle volumes (Blateral_ventricle=0.02 [~0.00; 0.04], after sociodemographic, behavioral, cardio-vascular quality characteristics. not modified or Conclusion We found increments lower size, could associate increased dementia-risk adults. Support (If Any) This work supported National Institute on (R01AG048642, RF1AG054548, R01AG063868) Heart Lung Blood (R01HL098297). Dr. González also receives additional support P30AG59299. carried out collaborative contracts Heart, Lung, (NHLBI) University North Carolina (N01-philip glass beck HC65233), Miami (N01-HC65234), Albert Einstein College Medicine (N01-HC65235), Northwestern (N01-HC65236), San Diego State (N01-HC65237). following Institutes/Centers/Offices contribute HCHS/SOL through transfer funds NHLBI: Minority Disparities, Deafness Other Communication Disorders, Dental Craniofacial Research, Diabetes Digestive Kidney Diseases, Neurological Disorders Stroke, NIH Institution-Office Dietary Supplements.